cellular and molecular determinants of all trans retinoic
ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY Low
2 Centritto et al. (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer Luminal phenotype and RAR expression. EMBO Mol Med 7 950–972. 3 Brugnoli et al. (2016) PLC-β2 is modulated by low oxygen availability in breast tumor cells and
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Cellular and molecular determinants of all‐trans retinoic
Cellular and molecular determinants of all All‐trans retinoic acid (ATRA) is the primary vitamin A metabolite and a promising agent in the treatment/chemoprevention of breast cancer. Breast cancer is very heterogeneous being a collection of different diseases. A rational use of ATRA in breast cancer requires the definition of the
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International Union of Pharmacology. LX. Retinoic Acid
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα RARβ and RARγ) members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all- trans -retinoic acid. Retinoids regulate a wide variety of essential biological processes such as vertebrate embryonic morphogenesis and organogenesis cell growth arrest
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Mutational Analysis Reveals That All-trans-retinoic acid
Siegfried Keidel François P. Y. Lamour Christian M. Apfel
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Cellular and molecular determinants of all- retinoic acid
neity were profiled for all-trans retinoic acid (ATRA) sensitivity. Luminal and ER (estrogen-receptor-positive) cell lines are gener- ally sensitive to ATRA while refractoriness/low sensitivity is associ- ated with a Basal phenotype and HER2 positivity.
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Mutational Analysis Reveals That All-trans-retinoic acid
Siegfried Keidel François P. Y. Lamour Christian M. Apfel
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Molecular)Determinants)of Retinoic) AcidMetabolism
Molecular)Determinants)of Retinoic) AcidMetabolism)–)) Embryonic)DevelopmentandBeyond • Cellular differentiation 11-cis retinal Visual Chromophore Retinaldehyde all-trans-retinoic acid (ATRA) 4-hydroxy-all-trans-retinoic acid CYP26A1 RDH10 DHRS3. RAR reporter mouse model
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Molecular determinants of nuclear receptor–corepressor
In this experiment we utilized N-CoR-specific anti-IgG to immunoprecipitate sheared chromatinized DNA prepared from cells cultured in the presence or absence of all-trans retinoic acid. As shown in Figure B N-CoR could be cross-linked to βRAR promoter
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All-trans retinoic acid restored the osteogenic ability of
determinants in the pathogenesis of OS. Therefore restoring the normal osteogenic ability of BMP9 in OS cells might contribute to the treatment of OS. All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway NIAN WU1 2 RUIDONG LI1 ZIJUN MENG1 MAO NIE1 QIANZHAO CHEN2 3
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Bcl-2 is a key regulator for the retinoic acid-induced
Mar 27 2006 · Effects of all-trans retinoic acid (ATRA) on cell proliferation of LA-N-5 RTBM1 CHP134 and NB-39-nu neuroblastoma-derived cell lines.(a) Growth curves of the indicated neuroblastoma cell
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Gabriela ParoniAcademia.edu
Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer Luminal phenotype and RARα expression more by Gabriela Paroni Forty-two cell lines recapitulating mammary carcinoma heterogeneity were profiled for all-trans retinoic acid (ATRA) sensitivity.
Get PriceRole of Retinoic Acid (RA) in Spermatogonial
Jan 01 2016 · Spermatogonial differentiation requires all-trans retinoic acid (ATRA referred to as RA) the molecular and cellular events downstream of RA remain largely provides a potential mechanistic explanation for the increased translational efficiency of repressed mRNAs encoding determinants of spermatogonial differentiation such as KIT
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Mutational Analysis Reveals That All-trans-retinoic acid
Siegfried Keidel François P. Y. Lamour Christian M. Apfel
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Bcl-2 is a key regulator for the retinoic acid-induced
Mar 27 2006 · Effects of all-trans retinoic acid (ATRA) on cell proliferation of LA-N-5 RTBM1 CHP134 and NB-39-nu neuroblastoma-derived cell lines.(a) Growth curves of the indicated neuroblastoma cell
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Retinoic acid signaling in cancer The parable of acute molecular and cellular determinants of APL sensitivity to treat-ments have also been only partially elucidated. Finally although as several isomers the most common of which is all- trans RA. RA receptor alpha (RARA) was the first receptor for all- trans
Get PricePhase I clinical trial repurposing all-trans retinoic acid
Sep 24 2020 · Arrieta O. et al. Randomized phase II trial of all-trans-retinoic acid with chemotherapy based on paclitaxel and cisplatin as first-line treatment in patients with advanced non-small-cell lung
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Retinoic acid signalling during development Development
Retinoic acid (RA) is a vitamin A-derived non-peptidic small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs) converting them from transcriptional repressors to activators. The distribution and levels of RA in embryonic tissues are tightly controlled by regulated synthesis through the action of specific retinol and retinaldehyde dehydrogenases and by degradation via
Get PriceBcl-2 is a key regulator for the retinoic acid-induced
Mar 27 2006 · Effects of all-trans retinoic acid (ATRA) on cell proliferation of LA-N-5 RTBM1 CHP134 and NB-39-nu neuroblastoma-derived cell lines.(a) Growth curves of the indicated neuroblastoma cell
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CRYSTAL-STRUCTURES OF CELLULAR RETINOIC ACID-BINDING
crystal-structures of cellular retinoic acid-binding protein-i and protein-ii in complex with all-trans-retinoic acid and a synthetic retinoid KLEYWEGT GJ Uppsala University Teknisk-naturvetenskapliga vetenskapsområdet Faculty of Science and Technology Biology Department of Cell and Molecular
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Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer Luminal phenotype and RARα expression. PLoS Pathog 7 950 PMID
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Retinoic acid receptors From molecular mechanisms to
Feb 01 2015 · Retinoic acid (RA) the major bioactive metabolite of retinol or vitamin A induces a spectrum of pleiotropic effects in cell growth and differentiati
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Structural Determinants of the Ligand-Binding Site of the
May 01 2002 · Biochemistry All Publications/Website. OR SEARCH CITATIONS
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Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer Luminal phenotype and RARα expression. PLoS Pathog 7 950 PMID
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All-trans retinoic acid mediates DUOX2 expression and
DUOX1 and DUOX2 are members of the NADPH oxidase family that are specifically regulated to produce hydrogen peroxide in epithelia of the thyroid gastrointestinal tract and respiratory tract. The
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Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer Luminal phenotype and RARα expression. PLoS Pathog 7 950 PMID
Get PriceCellular Retinol-binding Proteins Are Determinants of
THE JOURNAL OF BIOLOGICAL CHEMISTRY Q 1993 by The American Society for Biochemistry and Molecular Biology Inc. Vol. 268 No. 11 Issue of April 15 pp. 1993 Printed in U.S.A. Cellular Retinol-binding Proteins Are Determinants of Retinol Uptake and Metabolism in Stably Transfected Caco-2 Cells
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All-trans retinoic acid induces cellular senescence via
Nov 28 2011 · We here present a new anti-tumor mechanism of all- trans retinoic acid (ATRA). ATRA induced several biomarkers of cellular senescence including irreversible G 1 arrest morphological changes senescence-associated β-galactosidase and heterochromatin foci in HepG2 cells.
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All-trans-retinoic acid inhibits growth of human
All-trans-retinoic acid (ATRA) has become a first-line chemotherapeutic agent in the treatment of certain leukemias however the effect of ATRA on pancreatic tumors is unknown. The purpose of this study was to determine the effect of ATRA on the growth characteristics of both exocrine and endocrine human pancreatic cancer cell lines.
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Retinoid‐binding proteins structural determinants
deters the low molecular weight retinol-binding protein (21 000) from being filtered by the kidney glomeruli (12). Whether utilized as retinol retinal or retinoic acid vitamin A is transported to the target cells by RBP as all-trans retinol and only retinol triggers secretion of RBP. However in vitro
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